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Rab5 is involved in the process of mitophagy in SKP/SKO reprogramming. (A) Representative images of mitophagosomes in MEFs undergoing SKP/SKO reprogramming at d 5 with shRNA against Rab5 or Luc as control; scale bar: 10 µm. (B) Quantification of mitophagosomes in MEFs undergoing reprogramming with SKP/SKO plus shRab5 or shLuc (n = 20; *** P < 0.001). (C) Model of mitophagy in SKP/SKO reprogramming.
