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. 2017 Aug 17;6(9):1364–1374. doi: 10.1242/bio.024927

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — A new model of 75% ICR mice exhibits severe clinical manifestations. (A) Schematic representation of the surgeries and intestinal tissue collections. The distal 25 cm of the small intestine (∼75% of the small intestine) and cecum were resected in the 75% ICR model. The site of transection and anastomosis in sham surgery is also shown. The small and large intestines are divided into seven segments in this study and designated as D through C2. The middle 1 cm regions of the segments (gray boxes) were harvested for gene expression and histological analyses. (B) Kaplan–Meier survival curves for mice underwent 75% ICR (n=6) or sham operation (n=6). Statistical significance was assessed by log-rank test. (C) Mice were randomly assigned to un-operated control (Control), sham operation group (Sham) or those undergoing 75% ICR (ICR). The average body weight on 14 POD in each cohort is shown (n=6 for each group). Data are presented as means±s.e.m., **P<0.01 (Mann-Whitney U test).