Table 1.
Baseline characteristics of patients newly initiated with treatment from March 2015 until February 2016. All numbers are percentages unless otherwise stated
| Variable | Overall | ASA | Warfarin | Dabigatran | Rivaroxaban | Apixaban | p value |
|---|---|---|---|---|---|---|---|
| Number of patients | 6765 | 453 | 1691 | 717 | 770 | 3134 | |
| Male sex | 54.7 | 54.1 | 54.9 | 60.4 | 54.4 | 53.4 | 0.022 |
| Age | |||||||
| Mean age (years) | 74.3 | 75.1 | 74.9 | 70.4 | 73.7 | 74.8 | <0.001 |
| 0–65 | 20.3 | 24.9 | 17.9 | 29.7 | 20.9 | 18.6 | |
| 66–75 | 32.2 | 20.1 | 30.5 | 37.7 | 35.2 | 32.8 | |
| 76–85 | 30.1 | 28.3 | 33.9 | 22.7 | 29.6 | 30.1 | |
| ≥86 | 17.5 | 26.7 | 17.6 | 9.9 | 14.3 | 18.5 | |
| CHA2DS2-VASc score | |||||||
| CHADSVASc (mean) | 3.67 | 3.77 | 3.89 | 3.17 | 3.56 | 3.69 | <0.001 |
| 0 | 4.4 | 4.4 | 4.1 | 8.6 | 4.0 | 3.7 | <0.001 |
| 1 | 9.9 | 10.6 | 7.2 | 14.4 | 11.6 | 9.9 | |
| 2–4 | 52.5 | 47.9 | 52.5 | 51.2 | 53.9 | 53.2 | |
| ≥5 | 33.2 | 37.1 | 36.3 | 25.8 | 30.5 | 33.2 | |
| Comorbidities included in CHA2DS2-VASc score | |||||||
| Chronic heart failure | 26.4 | 30.5 | 30.7 | 17.0 | 25.8 | 25.8 | <0.001 |
| Hypertension | 70.2 | 65.6 | 73.9 | 63.7 | 69.1 | 29.4 | <0.001 |
| Age ≥ 75 | 50.6 | 56.5 | 54.9 | 34.5 | 47.7 | 51.9 | <0.001 |
| Age 65–74 | 31.8 | 20.5 | 29.2 | 38.9 | 34.8 | 32.5 | <0.001 |
| Diabetes mellitus | 19.2 | 17.0 | 23.1 | 15.3 | 19.1 | 18.3 | <0.001 |
| Stroke or embolism | 22.4 | 24.7 | 20.8 | 26.2 | 19.5 | 22.8 | 0.007 |
| Vascular disease | 28.3 | 35.5 | 35.2 | 21.2 | 27.5 | 25.3 | <0.001 |
| Female sex | 45.3 | 45.9 | 45.1 | 39.6 | 45.5 | 46.6 | 0.022 |
| ATRIA score | |||||||
| ATRIA (mean) | 2.6 | 2.9 | 2.9 | 1.9 | 2.4 | 2.6 | <0.001 |
| 0–3 | 76.7 | 70.4 | 72.0 | 85.5 | 79.9 | 77.3 | <0.001 |
| 4 | 6.2 | 7.9 | 6.8 | 6.7 | 6.0 | 5.6 | |
| ≥5 | 17.1 | 21.6 | 21.2 | 7.8 | 14.2 | 17.1 | |
| Comorbidities included in ATRIA score | |||||||
| Anemia | 17.3 | 21.4 | 20.4 | 11.3 | 15.7 | 16.9 | <0.001 |
| Renal disease | 8.7 | 11.7 | 13.2 | 3.2 | 6.4 | 7.7 | <0.001 |
| Age ≥75 | 50.6 | 56.5 | 54.9 | 34.5 | 47.7 | 51.9 | <0.001 |
| Serious bleeding | 9.8 | 12.1 | 9.7 | 8.9 | 7.8 | 10.2 | 0.106 |
| Hypertension | 70.2 | 65.6 | 73.9 | 63.7 | 69.1 | 29.4 | <0.001 |
| Prescriber category | |||||||
| Primary care | 31.8 | 28.0 | 48.8 | 18.7 | 30.9 | 26.5 | <0.001 |
| Cardiology | 26.5 | 14.3 | 17.8 | 33.2 | 29.4 | 30.7 | <0.001 |
| Internal medicines | 19.4 | 14.6 | 13.8 | 19.2 | 19.1 | 23.3 | <0.001 |
| Geriatrics | 7.6 | 15.5 | 8.2 | 5.2 | 4.5 | 7.5 | <0.001 |
| Other/unknown | 14.7 | 27.6 | 11.4 | 23.7 | 16.1 | 12.0 | <0.001 |
| Complicating comorbidities | |||||||
| Liver disease | 2.1 | 4.6 | 2.5 | 1.3 | 2.9 | 1.6 | <0.001 |
| Dementia | 5.0 | 11.3 | 2.8 | 2.5 | 6.1 | 5.5 | <0.001 |
| VTE | 9.6 | 5.7 | 10.6 | 6.8 | 15.5 | 8.8 | <0.001 |
| Alcoholism | 6.3 | 8.6 | 5.8 | 7.5 | 6.5 | 5.8 | 0.097 |
| Cancer | 24.8 | 26.7 | 25.6 | 19.4 | 23.2 | 25.6 | 0.005 |
| COPD | 10.7 | 11.3 | 10.9 | 7.8 | 9.7 | 11.4 | 0.069 |
| Frequent falls | 15.7 | 19.2 | 15.1 | 12.1 | 17.4 | 15.9 | 0.010 |
| Obesity | 9.8 | 7.9 | 10.4 | 11.2 | 10.3 | 9.3 | 0.290 |