Skip to main content
. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Exp Eye Res. 2016 May 13;158:124–136. doi: 10.1016/j.exer.2016.05.011

Fig. 1.

Fig. 1

Bidirectional signaling. The figure illustrates how changes made to the extracellular matrix (ECM) by the cell can in turn influence the signals perceived by the integrin adhesion complex (IAC) and alter the biological properties of the cell. Changes perceived by the IAC can be chemical in nature such as the expression of new ECM proteins (yellow circles) or physical due to a change in the 3-D architecture of the ECM or rigidity of the ECM. These physical changes can be triggered by contractile forces applied by cells through the IAC.