Table 4.

Change from baseline in vital signs over 12 weeks.

	UP1306	Glucosamine and chondroitin combination	Placebo	p value
Systolic BP mm Hg	5.5 ± 13.3 (43)	1.0 ± 16.2 (45)	−1.7 ± 14.0 (43)	0.073#
	5 (−25–34)	3 (−42–30)	−1 (−35–22)
	p = 0.010∗	p = 0.688	p = 0.436
Diastolic BP mm Hg	2.6 ± 7.9 (42)	1.6 ± 8.7 (45)	−1.2 ± 7.1 (43)	0.077#
	2.5 (−12–20)	3 (−28–18)	−1 (−20–17)
	p = 0.036∗	p = 0.230	p = 0.288
Heart rate beats/minute	−1.2 ± 7.3 (43)	1.3 ± 7.7 (45)	−1.3 ± 8.0 (43)	0.205
	−1 (−26–12)	1 (−15–18)	−1 (−18–14)
	p = 0.304	p = 0.277	p = 0.273

^∗Significant: p ≤ 0.05;  ^#trending toward significance: p < 0.10, but p > 0.05.