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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Circ Heart Fail. 2017 Sep;10(9):e003850. doi: 10.1161/CIRCHEARTFAILURE.117.003850

Figure 5.

Figure 5

Mouse heart under Langendorff 30min global ischemia followed by 1hr reperfusion. A. Normalized LV developed pressure indicates LV function recovery after ischemia/reperfusion(IR). On average, cTnIS200D hearts recovered better than NTG and cTnIS200A hearts. The baseline time point is 30 min after the isolated heart was cannulated and perfused via Langendorff system when developed pressure was stabilized. B. A representative image of Western blot with anti-cTnI McAb 8I-7 shows that cTnI proteolysis is more likely to be detected in NTG and cTnIS200A than cTnIS200D heats under IR treatment. No cTnI proteolysis was observed in mice without IR as demonstrated in the 2nd, 10th and 11th lane (from left to right). C. Quantitative data of the amount of intact cTnI in the heart tissue without and without I/R. n=5. *P<0.05 indicates significance as compared with NTG and cTnIS200A after IR.