Table 2. In vivo LV hemodynamic measures on mice at baseline.

	NTG	cTnIS200D	cTnIS200A
Measures
Heart Rate (beat/min)	580 ± 12	554 ± 14	578 ± 16
Main Arterial Pressure (mmHg)	76.64 ± 4.46	67.53 ± 2.75	71.54 ± 1.82
End-systolic Pressure (mmHg)	94.16 ± 5.15	82.25 ± 3.54	87.40 ± 2.66
End-diastolic Pressure (mmHg)	4.71 ± 0.39	7.34 ± 0.76 ^*	4.89 ± 0.51
End-systolic Volume (μl)	14.69 ± 0.38	14.98 ± 0.36	14.37 ± 1.18
End-diastolic Volume (μl)	39.57 ± 0.97	40.19 ± 0.54	39.38 ± 1.48
Stroke Volume (μl)	24.88 ± 1.08	25.21 ± 0.68	25.01 ± 0.61
Cardiac Output (ml/min)	14.44 ± 0.76	13.95 ± 0.43	14.44 ± 0.50
Arterial Elastance	3.82 ± 0.22	3.29 ± 0.19	3.50 ± 0.10
Systolic Indices
Ejection Fraction (%)	62.67 ± 1.34	62.66 ± 1.04	63.97 ± 1.99
dP/dt_max (mmHg/s)	11096 ± 1015	11628 ± 760	10324 ± 374
dP/dt_max/iP (s^-1)	188.61 ± 9.41	226.02 ± 7.89 ^*	189.57 ± 4.34
Power_max/EDV	38.27 ± 3.18	27.97 ± 2.05 ^*	36.38 ± 1.97
SW	2402 ± 200	2114 ± 76	2253 ± 99
PRSW	87.17 ± 6.82	93.06 ± 8.36	91.79 ± 4.81
Diastolic Indices
dP/dt_min	9130 ± 901	6255 ± 483 ^*	8412 ± 498
Tau (ms)	5.27 ± 0.36	6.90 ± 0.38 ^*	5.25 ± 0.21
Peak Filling Rate-EDV	36.93 ± 2.61	28.51 ± 1.79 ^†	31.01 ± 1.95

P<0.05 compared to NTG and cTnIS200A.

^†

P<0.05 compared to NTG. n=5. End-diastolic volume presents preload. Arterial elastance is a measure of afterload. Abbreviations: EF, ejection fraction; dP/dt_max, peak rate of pressure rise; dP/dt_max/iP, peak rate of pressure normalized to instantaneous pressure, a preload-independent index of contractility during isovolumic contraction; Power_max/EDV, maximal power normalized to EDV reflecting contractility during LV ejection of blood; −dP/dt_min, peak rate of pressure decay during isovolumic relaxation, which is preload dependent; Tau, isovolumic relaxation time constant, a preload-independent index; PFR/EDV, peak ventricular filling rate normalized to EDV.