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Stepwise management of High-risk keratoplasty
| 1. Potent and frequent topical steroids -- continued indefinitely on a tapering dose |
| 2. Topical tacrolimus (or CsA) as adjunctive therapy -- continued indefinitely |
| 3. Systemic steroids peri-operatively |
| 4. Systemic mycophenolate (azathioprine or rapamycin alternative) |
| 5. Systemic tacrolimus (or cyclosporine) in addition to mycophenolate |
