Table 1.

Characteristics of patients with frostbite on the scalp following the use of cold caps.

Case No.	Age/Sex	Cancer	Chemo Regimen	Cold Cap Usage Details				Onset	Follow-up††	Potential contributory factors
				Make	Pre-infusion	During infusion	Post-infusion
1	49/F	Breast	TCHP	Penguin™	60′	2.5hrs.	5hrs.	Cycle 3	Mild persistent alopecia (at 5 months)	Lack of adequate padding between the cold cap and skin; duration of post-infusion cooling
2	55/F	Breast	AC➔T	Elasto-Gel™	15′	60′	50mins.	Cycle 3	Mild persistent alopecia (at 4 months)	Pre-existing alopecia; lack of padding; duration of post-infusion cooling?
3	58/F	Breast	PH	Penguin™	50′	30′	2.5hrs.	Cycle 4†	Alopecia resolved (at 2 months)	Pre-existing diffuse alopecia; duration of post-infusion cooling
4	50/F	Breast	CMF	Penguin™	50′	60′	4.5hrs.	Cycle 1	Mild persistent alopecia, skin sensitivity (at 6 months)	Lack of adequate padding; duration of post-infusion cooling

TCHP – docetaxel, carboplatin, trastuzumab, pertuzumab; AC-T – adriamycin and cyclophosphamide, followed by paclitaxel; PH – paclitaxel, trastuzumab; CMF – cyclophosphamide, methotrexate, fluorouracil

^†this includes two complete cycles of paclitaxel and two cycles of albumin-bound paclitaxel

^†it must be noted that the findings occurred in some patients, despite the use of topical minoxidil 5% lotion