Table 3.
Hazard ratios with 95% confidence intervals for risk of incident myocardial infarction by QRS/T angle category.
| Events/1000 person years | Model-1a, HR (95% CI) | p Value | Model-2b, HR (95% CI) | p Value | |
|---|---|---|---|---|---|
| Risk of incident silent myocardial infarction (N = 9112) | |||||
| Spatial QRS/T angle | |||||
| Normal | 3.2 | 1 (ref.) | 1 (ref.) | ||
| Borderline | 5.3 | 1.66 (1.29–2.15) | <.0001 | 1.51 (1.16–1.96) | .0023 |
| Wide | 8.5 | 2.59 (1.79–3.73) | <.0001 | 2.00 (1.35–2.96) | .0005 |
| Frontal QRS/T angle | |||||
| Normal | 3.3 | 1 (ref.) | 1 (ref.) | ||
| Borderline | 4.7 | 1.31 (1.01–1.71) | .0437 | 1.23 (0.94–1.61) | .1372 |
| Wide | 9.4 | 2.72 (1.92–3.84) | <.0001 | 2.28 (1.59–3.27) | <.0001 |
| Risk of incident myocardial infarction (both of silent and clinical, N = 9498) | |||||
| Spatial QRS/T angle | |||||
| Normal | 7.6 | 1 (ref.) | 1 (ref.) | ||
| Borderline | 9.8 | 1.30 (1.09–1.56) | .0039 | 1.17 (0.97–1.41) | .1018 |
| Wide | 18.2 | 2.39 (1.87–3.07) | <.0001 | 1.87 (1.43–2.44) | <.0001 |
| Frontal QRS/T angle | |||||
| Normal | 7.4 | 1 (ref.) | 1 (ref.) | ||
| Borderline | 10.4 | 1.35 (1.13–1.60) | .0009 | 1.25 (1.05–1.49) | .0147 |
| Wide | 17.9 | 2.25 (1.75–2.89) | <.0001 | 1.86 (1.43–2.41) | <.0001 |
Cutpoints listed in Table 2: normal, QRS/T angle ≤ 75th percentile; borderline, >75th percentile and ≤ 95th percentile; wide, >95th percentile.
a
Model 1: adjusted for age, sex, and race.
b
Model 2: adjusted for the variables in Model-1 plus study site, body mass index, education, smoking status, systolic blood pressure, blood pressure-lowering medications, diabetes mellitus, ratio of total cholesterol to high-density lipoprotein, use of cholesterol-lowering medications, use aspirin, family history of coronary heart disease, ECG-LVH by Cornell voltage, and serum creatinine at baseline.