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Current clinical treatment options for articular joint damage. Treatment options depend on defect size and severity: (A) defects < 2 cm2; (B) 2 cm2 < defects < 3 cm2; (C) defect ≈ 4 cm2 or multiple defects; (D) end-stage degeneration. Reprinted from [4], Copyright (2010), with permission from Elsevier.
