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PAT detects reduced vessel density and increased HbO2 in trebananib-treated mice. (A) THb photoacoustic (PA) signal in tumor ROI is significantly elevated in vehicle- compared with trebananib-treated mice; no significant difference is observed in contralateral ROI. (B) In trebananib-treated group, HbO2-weighted signal increases significantly, whereas Hb-weighted signal decreases significantly, over same time course. *P < 0.05. **P < 0.01.
