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. Author manuscript; available in PMC: 2018 May 31.
Published in final edited form as: J Am Chem Soc. 2017 May 19;139(21):7264–7272. doi: 10.1021/jacs.7b01084

Figure 6. Copper complexes significantly extend time to death of mice exposed to BoNT/A.

Figure 6

BoNT/A (5 LD50 units) was administered i.p. to mice (n = 5 per group) which were then treated 1 h post-toxin s.c. with vehicle A, vehicle B, vehicle A + Cu(GTSM) at 4.6 mg/kg and vehicle B + Cu(MEDTC)2 at 7.6 mg/kg. The doses for both complexes equated to a copper dose of 1 mg/kg. Vehicle A: citrate/phosphate buffer containing 10% w/v β-CD and 4% v/v DMSO. Vehicle B: saline containing 2.5% w/v β-CD, 2% v/v DMSO and 0.9% v/v benzyl alcohol. Data represent mean ± SEM with individual values shown. ***P < 0.001 by t test. Mice treated with complex only without toxin (n = 3 per complex) showed complete survival.