Table 1. Characteristics of stereotactic radiosurgery and ipilimumab therapy studies (2012-2015) selected for analysis.

^aSilk, et al. included patients receiving WBRT as primary radiotherapy; these patients were excluded for the rest of our review [30]. Abbreviations: SRS = stereotactic radiosurgery; ipi = ipilimumab; RT = radiotherapy; DS-GPA = diagnosis-specific graded prognostic assessment; KPS = Karnofsky performance score; WBRT = whole-brain radiotherapy; fr = fraction; NR = not reported [29-32].

	Patel, et al. [29]	Silk, et al. [30]	Mathew, et al. [31]	Knisely, et al. [32]
Cohort size: SRS plus Ipi	20	17	25	27
Cohort size: SRS alone	34	16	33	50
RT dosea (SRS modality)	15 - 21 Gy, 1 - 5 fr (linear accelerator)	SRS: 14 - 24 Gy, 1 - 5 fr (linear accelerator); WBRT: 30 - 37.5 Gy, 10 - 13 fr	15 - 20 Gy, 1 fr (Gamma Knife)	RT dose NR (Gamma Knife)
Ipi dose	3 mg/kg; concurrent, sequential	3 mg/kg; concurrent, sequential	3, 10 mg/kg; concurrent, sequential	NR; sequential
DS-GPA/KPS	DS-GPA (0-2): 45% vs. 32.4%, p = 0.43	DS-GPA (0-2): 54.5% vs. 54.1%, p = 0.99	Median KPS (range): 90 (80-90) vs. 90 (60-90), p = 0.44	DS-GPA (0-2): 40.7% vs. 64.0%, p = 0.21