Figure 2.

(a) In vitro specificity test of ⁵⁷Co-NOTA-PEG₂-RM26 binding to GRPR on PC-3 (human prostate cancer) cells. Presaturation of receptors with unlabeled NOTA-PEG₂-RM26 caused significant (p < 0.05) reduction of cell-bound ⁵⁷Co-NOTA-PEG₂-RM26 radioactivity. (b) Binding and internalization of ⁵⁷Co-NOTA-PEG₂-RM26 at 37°C by PC-3 cells. Data are normalized to a maximum cell-bound radioactivity and presented as average value from 3 cell dishes ± SD. Not all error bars are visible due to the small standard deviations.