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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Wiley Interdiscip Rev Comput Mol Sci. 2017 Apr 19;7(5):e1309. doi: 10.1002/wcms.1309

Figure 8. The CASP blind test of protein structure prediction.

Figure 8

The x-axis represents the degree to which known proteins can be used as starting models for predicting target protein structure. Blue band represents the historical average over 20 years of CASP events, showing that bioinformatics methods have been challenged to predict protein structures. The triangles shows that, when given some additional information beyond the amino-acid sequence, the MELD physical method (black triangles) gives comparable predictions to the best bioinformatics methods (one of which is Rosetta, red triangles).