Table 2. Relationship between anatomical primary tumor location (compartment and sympathetic origin) of neuroblastomas and their genomic profile.
| Genomic profile(1) | NCA | SCA | MNA | Total | P-value | |
|---|---|---|---|---|---|---|
| N = | 50 | 47 | 36 | 133 | ||
| Anatomic compartment | Neck | 9 | 0 | 0 | 9 | < .0001 |
| Chest | 13 | 7 | 1 | 21 | ||
| Abdomen | 20 | 40 | 35 | 95 | ||
| Pelvis | 8 | 0 | 0 | 8 | ||
| Sympathetic origin | Cervical | 9 | 0 | 0 | 9 | < .0001 |
| upper cervical | 4 | 0 | 0 | 4 | ||
| stellate ganglion | 5 | 0 | 0 | 5 | ||
| Paravertebral | 21 | 7 | 0 | 28 | ||
| upper chest | 8 | 5 | 0 | 13 | ||
| lower chest | 5 | 1 | 0 | 6 | ||
| lumbar | 3 | 1 | 0 | 4 | ||
| presacral | 5 | 0 | 0 | 5 | ||
| Periarterial | 9 | 15 | 3 | 27 | ||
| mediastinal | 0 | 1 | 1 | 2 | ||
| celiac | 0 | 4 | 0 | 4 | ||
| pre-renal | 4 | 6 | 1 | 11 | ||
| median subrenal | 1 | 2 | 1 | 4 | ||
| Zuckerkandl organ | 0 | 1 | 0 | 1 | ||
| sup.hypog. plexus | 3 | 0 | 0 | 3 | ||
| iliac | 1 | 1 | 0 | 2 | ||
| Adrenal gland | 11 | 25 | 33 | 69 | ||
(1) NCA: numerical-only chromosome alterations; SCA: segmental chromosome alterations; MNA: MYCN amplification.