Table 3. Relationships between imaging phenotypes of neuroblastomas and outcome (univariate analysis).

		N	5Y-EFS(1) ± SE	RR(2) 95%CI	P-value	5Y-OS(1) ± SE	RR(3) 95%CI	P-value
Anatomical compartment	Neck	9	77.8 ± 13.9	2.22 [1.08–4.53](4)	.17	88.9 ± 10.5	4.79 [1.47–15.64] (4)	.037
	Chest	21	74.7 ± 9.8			95 ± 4.9
	Abdomen	95	52.1 ± 5.2			66.9 ± 4.9
	Pelvis	8	75 ± 15.3			100
Sympathetic system origin	Cervical	9	77.8 ± 13.9	1	.11	88.9 ± 10.5	1	.0016
	Paravertebral	28	77.6 ± 8.1	0.90 [0.18–4.44]		100	0.31 [0.02–5.02]
	Periarterial	27	51.9 ± 9.6	2.19 [0.49–9.72]		81.5 ± 7.5	1.75 [0.2–15.01]
	Adrenal	69	51.4 ± 6.1	2.29 [0.55–9.57]		60.2 ± 6	4.29 [0.58–31.52]
IDRF	No	11	72.7 ± 13.4	1	.37	90.9 ± 8.7	1	.21
	Yes	122	57.3 ± 4.6	1.69 [0.53–5.41]		73.1 ± 4.1	3.35 [0.46–24.48]
Tumor Volume(5)	≤ 160 mL	66	64 ± 6	1	.23	83.8 ± 4.7	1	.0088
	> 160 mL	66	53.8 ± 6.2	1.39 [0.8–2.39]		64.9 ± 5.9	2.52 [1.23–5.14]
Tumor volume decrease	≤ 50%	16	50 ± 12.5	1 [0.44–2.28]	.58	87.5 ± 8.3	0.39 [0.00–1.32]	.11
	50–89%	53	59.6 ± 6.9	0.74 [0.4–1.37]		76.7 ± 5.9	0.53 [0.26–1.09]
	≥ 90%	42	52.3 ± 7.7	1		59.3 ± 7.6	1

(1) EFS: event-free survival; OS: overall survival; SE: standard error. The mean follow-up of the cohort was 83 months (range, 1–175 mo). The 5-year EFS and OS of the entire cohort were 58.6% (+/- 4.3%) and 74.6% (+/- 3.8%), respectively.

(2) RR: relative risk of events; CI: confidence interval.

(3) RR: relative risk of death.

(4) Relative risk has been estimated in abdominal tumours compared to cervical, thoracic or pelvic tumours, as no death occurred in patients with pelvic tumours (RR could not be estimated by the Cox model for this subgroup of patients). For homogeneity of results, the same cluster has been done for estimating EFS’ hazard ratio. However, Logrank tests compare survival and EFS of the 4 anatomical compartments.

(5) (1 missing data).