Table 2.
64Cu-NOTA-ZHER2:S1 and 64Cu-NODAGA-ZHER2:S1 biodistribution in mice bearing HER2-positive (SKOV-3) xenografts.
| Uptake (% ID/g) | ||||||
|---|---|---|---|---|---|---|
| 2 h | 6 h | 24 h | ||||
| 64Cu-NOTA- ZHER2:S1 | 64Cu-NODAGA- ZHER2:S1 | 64Cu-NOTA- ZHER2:S1 | 64Cu-NODAGA- ZHER2:S1 | 64Cu-NOTA- ZHER2:S1 | 64Cu-NODAGA- ZHER2:S1 | |
| Blood | 1.0 ± 0.2 | 0.32 ± 0.05∗ | 1.4 ± 0.2 | 0.26 ± 0.04∗ | 1.15 ± 0.08 | 0.5 ± 0.1∗ |
| Lung | 3.0 ± 0.5 | 0.8 ± 0.1∗ | 5.9 ± 0.6 | 1.1 ± 0.2∗ | 4.7 ± 1.0 | 2.0 ± 0.6∗ |
| Liver | 10.9 ± 0.6 | 2.8 ± 0.5∗ | 17 ± 3 | 3.6 ± 0.5∗ | 11.3 ± 0.9 | 5 ± 1∗ |
| Spleen | 1.6 ± 0.2 | 0.56 ± 0.09∗ | 2.6 ± 0.7 | 0.63 ± 0.09∗ | 3.1 ± 0.5 | 1.2 ± 0.3∗ |
| Stomach | 3.3 ± 0.3 | 0.8 ± 0.1∗ | 5.2 ± 0.3 | 1.1 ± 0.2∗ | 3.5 ± 0.4 | 1.6 ± 0.4∗ |
| Kidney | 207 ± 35 | 290 ± 35∗ | 69 ± 7 | 226 ± 41∗ | 14 ± 1 | 110 ± 25∗ |
| Tumor | 17 ± 2 | 12 ± 3∗ | 17 ± 4 | 10 ± 2∗ | 10 ± 1 | 11 ± 4∗ |
| Muscle | 0.45 ± 0.06 | 0.16 ± 0.05∗ | 0.55 ± 0.09 | 0.14 ± 0.03∗ | 0.55 ± 0.04 | 0.25 ± 0.05∗ |
| Bone | 1.0 ± 0.1 | 0.35 ± 0.07∗ | 1.16 ± 0.05 | 0.30 ± 0.05∗ | 1.1 ± 0.2 | 0.5 ± 0.2∗ |
Data are presented as mean ± SD for four mice
∗Significant difference between 4Cu-NOTA-ZHER2:S1 and 64Cu-NODAGA-ZHER2:S1 at the given time point.