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Schematic diagram of LNP constructs. DSPE-PEG-acetBr (acetBr-LNP) and DSPE-PEG-maleimide (mal-LNP) were conjugated to the DOTA-anti-PSMA scFv-cys or DOTA-monoacetamidoethanethiol (DOTA-thiol). LNP, lipid nanoparticles; DSPE, distearoyl phosphatidylethanolamine monomethoxy; PEG, polyethylene glycol; DOTA, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid; PSMA, prostate specific membrane antigen.
