Table 2.
Radioactivity accumulation (data obtained from MicroPET) in selected organs of PC-3 tumor bearing nude mice after injection of [68Ga] Ga-NOTA-MAL-FSH1 at different time points (n = 5/group, mean ± SD).
| Uptake (% ID/g) | [68Ga] Ga-NOTA-MAL-FSH1 | [68Ga] Ga-NOTA-MAL-FSH1 block | ||||
|---|---|---|---|---|---|---|
| 0.5 h | 1 h | 2 h | 0.5 h | 1 h | 2 h | |
| Tumor | 1.87 ± 0.10 | 1.26 ± 0.06 | 0.71 ± 0.10 | 0.36 ± 0.08 | 0.31 ± 0.04 | 0.15 ± 0.03 |
| Muscle | 0.25 ± 0.02 | 0.21 ± 0.04 | 0.13 ± 0.03 | 0.28 ± 0.09 | 0.24 ± 0.03 | 0.11 ± 0.01 |
| Liver | 0.80 ± 0.07 | 0.44 ± 0.06 | 0.57 ± 0.12 | 0.23 ± 0.07 | 0.15 ± 0.03 | 0.12 ± 0.06 |
| Kidney | 18.69 ± 3.44 | 21.10 ± 3.64 | 14.05 ± 2.76 | 15.27 ± 2.89 | 14.10 ± 3.01 | 13.78 ± 1.96 |