Table 3.

Neonatal outcomes by prenatal marijuana exposure for women who delivered at <28 weeks (n=569)

	No Marijuana n=534	Marijuana n=35	p-value
Adverse neonatal outcome*	336 (62.8)	19 (54.3)	0.37
Death before hospital discharge	73 (13.7)	4 (11.4)	>0.99
Missing	6 (1.1)	0
Severe NEC	43 (8.0)	4 (11.1)	0.52
Missing	6 (1.1)	0
Grade 3 or 4 IVH	27 (4.9)	1 (3.6)	>0.99
Missing	33 (6.2)	0
BPD	260 (48.7)	13 (37.1)	>0.99
Missing	6 (1.1)	0
PVL	18 (3.5)	1 (2.8)	>0.99
Missing	38 (6.9)	0
Adverse early childhood outcome**	167 (31.3)	15 (42.9)	0.19
Death prior to age 2	14 (2.6)	1 (2.8)	>0.99
Moderate or severe cerebral palsy	23 (4.3)	0	0.39
Missing	17 (3.2)	1 (2.9)
MDI <70	107 (20.0)	10 (28.6)	0.25
Missing	147 (27.5)	10 (28.6)
PDI <70	99 (18.6)	9 (25.7)	0.24
Missing	138 (25.8)	10 (28.6)
Other outcomes
Intrauterine growth restriction	34 (6.4)	1 (2.9)	0.72
Small for gestational age ^ (<10th percentile)	10 (1.9)	0	>0.99
Large for gestational age ^ (≥90th percentile)	51 (9.6)	1 (2.9)	0.24
Any cerebral palsy	54 (9.8)	1 (1.8)	0.24
Missing	19 (3.5)	1 (2.8)
MDI<85	219 (41.0)	18 (51.4)	0.15
Missing	147 (27.5)	10 (28.6)
PDI <85	182 (34.1)	15 (42.9)	0.22
Missing	138 (25.8)	10 (228.6)

Abbreviations: NEC, necrotizing enterocolitis; IVH, intraventricular hemorrhage, PVL, periventricular leukomalacia; BPD, bronchopulmonary dysplasia; MDI, mental developmental indices; PDI, psychomotor developmental indices

P value denotes association between marijuana exposure and variable using Fisher’s exact test

^*Composite Primary Short term outcome: Death, Grade 3 or 4 IVH, PVL, NEC, BPD

^**Composite Primary Long term Outcome: Death before age 2, moderate or severe cerebral palsy, PDI or MDI <70

^{^}by sex and gestational age at delivery for US population