Table I.
Patient characteristics at diagnosis
| Characteristic | All (N=1039) | Relapsed (N=250) | |
|---|---|---|---|
|
| |||
| Median age (range), years | 62 (18–92) | 61 (19–89) | |
|
| |||
| Age at diagnosis | |||
| <60 years | 475 (46%) | 114 (46%) | |
| >60 years | 564 (54%) | 136 (54%) | |
|
| |||
| Sex | |||
| Male | 577 (56%) | 157 (63%) | |
| Female | 462 (44%) | 93 (37%) | |
|
| |||
| Histology at diagnosis | |||
|
| |||
| DLBCL | 983 (95%) | 241 (96%) | |
|
| |||
| PMBL | 56 (5%) | 9 (4%) | |
|
| |||
| IPI at diagnosis | |||
|
| |||
| 0–1 | 349 (34%) | 47 (19%) | |
|
| |||
| 2 | 305 (29%) | 69 (28%) | |
|
| |||
| 3 | 251 (24%) | 93 (37%) | |
|
| |||
| 4 or 5 | 134 (13%) | 41 (16%) | |
|
| |||
| Stage at diagnosis | |||
| I/II | 382 (37%) | 54 (22%) | |
| III/IV | 647 (63%) | 194 (78%) | |
|
| |||
| LDH at diagnosis | |||
| >Upper limit of normal | 393 (42%) | 161 (75%) | |
| <Upper limit of normal | 543 (58%) | 55 (25%) | |
|
| |||
| 2 or more Extranodal sites at diagnosis | |||
| Yes | 215 (21%) | 60 (24%) | |
| No | 824 (79%) | 190 (76%) | |
|
| |||
| ECOG performance status at diagnosis | |||
| 0–1 | 857 (83%) | 186 (75%) | |
| 2–4 | 179 (17%) | 63 (25%) | |
|
| |||
| Any B symptoms at diagnosis | |||
| Yes | 256 (25%) | 84 (34%) | |
| No | 783 (75%) | 166 (66%) | |
|
| |||
| Bulky disease > 10 cm at diagnosis | |||
| Yes | 127 (12%) | 45 (18%) | |
| No | 912 (88%) | 205 (82%) | |
|
| |||
| Bone marrow involvement with DLBCL at diagnosis | |||
| Yes | 102 (10%) | 33 (13%) | |
| No | 937 (90%) | 217 (87%) | |
|
| |||
| Cell of origin (Hans) | |||
| GCB | 375 (64%) | 74 (59%) | |
| Non-GCB | 210 (36%) | 51 (41%) | |
|
| |||
| CNS involvement at diagnosis | |||
| Yes | 18 (2%) | 8 (3%) | |
| No | 1021 (98%) | 242 (97%) | |
|
| |||
| Creatinine at diagnosis | 0.9 (0.4–19.1) | 1.0 (0.4–4.4) | |
CNS, central nervous system; DLBCL, diffuse large B cell lymphoma; ECOG, Eastern Cooperative Oncology Group; GCB, germinal centre B cell-like; IPI, International Prognostic Index; LDH, lactate dehydrogenase; PMBL, primary mediastinal B cell lymphoma.