Analyses of combined 3VO and systemic LPS on neurological function. (A) Following basilar artery (BA) occlusion, mice undergo either sham dissection or 15-minute common carotid artery (CCA) occlusion with saline or IP LPS injection immediately following reperfusion. Effects of experimental procedures on weight (B) and core temperature (C). (D) Effects of experimental procedures on neurological functional scores assessed prior to BAO (Day −10), prior to BCCAO/sham (Day 0), at Day 1, and at Day 3. Values represent means ± SD (n = 3–4 per group). 3-way ANOVA: † ANOVA main effects, * Dunn-Sidak multiple comparisons. */†
p < 0.05, **/††
p < 0.01, †††
p < 0.001, ****/††††
p < 0.0001.