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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Neurobiol Aging. 2017 Aug 4;59:55–63. doi: 10.1016/j.neurobiolaging.2017.07.010

Table 3.

Association between the AD signature and delirium severity (CAM-S peak or CAM-S sum) in the delirium group only (N=32)

Model covariates Regression Coefficient (SE) 95% C.I. p-value R2 R2 change*
A) CAM-S Peak
Age (years) −0.03 (0.2) −0.36, 0.29 0.84
Female Sex 0.43 (1.4) −2.41, 3.27 0.76
AD signature −1.2 (0.5) −2.20, −0.27 0.014 0.21 0.20
B) CAM-S Sum
Age (years) 0.01 (0.6) −1.31, 1.32 0.99
Female Sex −2.3 (5.6) −13.83, 9.30 0.69
AD signature −6.0 (1.9) −9.83, −2.13 0.004 0.31 0.25

On average, a 1/10 mm reduction in AD signature cortical thickness is associated with an increase of 1.2 points on the CAM-S peak score and an increase of 6 points on the CAM-S summed score.

C.I.=Confidence Interval; AD signature=average cortical thickness (mm) in 9 bilateral cortical regions of interest; CAM-S= Confusion Assessment Method Severity score (peak=largest single CAM-S rating observed during hospitalization [possible range 0–19]; sum=summed value of CAM-S across all hospitalization days).

*

R2 change refers to the change in R2 after the AD signature was added to the covariates-only model (only age and sex as independent variables).