Table 4. Correlation of ammonia levels with plasma amino acids in patients with propionic acidemia during the clinical trial.

Statistical significance was calculated using analysis of variance. R² and p are indicated.

Amino Acid	R2	p
Alanine	0.07*	0.041
Arginine	0.29*	<0.001
Asparagine	0.01	0.380
Citrulline	0.13*	0.006
Cysteine	0.01	0.388
Glutamine	0.02	0.282
Glutamine + Glutamate	0.05	0.112
Glutamine + Glutamate + Alanine	0.09*	0.026
Glutamate	0.12*	0.008
Glycine	0.06	0.074
Histidine	0.02	0.240
Isoleucine	0.01	0.369
Leucine	0.11*	0.012
Lysine	0.52*	<0.001
Methionine	0.02	0.278
Ornithine	0.05	0.108
Phenylalanine	0.10*	0.014
Proline	0.006	0.582
Serine	0.02	0.246
Threonine	0.04	0.148
Tyrosine	0.13*	0.007
Valine	0.005	0.608

^*p <0.05 or better (indicated in bold).