Table 3.
| a: Relationship between the number of Metabolic Syndrome Criteria Met at Baseline and Primary/Secondary Endpoints ≤2 Criteria (No Metabolic Syndrome) Referent | ||||
|---|---|---|---|---|
| Number of Metabolic syndrome criteria met at baseline |
Event Number (%) |
HR1 (95%CI), p- value2 |
||
| Primary Endpoint | ≤2 | 96 (15.1%) | Referent, 0.5472 | |
| 3 | 48 (13.8%) | 0.923 (0.653, 1.305) | ||
| 4 | 185 (16.9%) | 1.113 (0.870, 1.425) | ||
| 5 | 218 (16.8%) | 1.115 (0.876, 1.418) | ||
| Secondary Endpoints | . | |||
| Constellation of CAD death, non-fatal MI, ischemic stroke or hospitalization for ACS | ≤2 | 62 (9.7%) | Referent, 0.2726 | |
| 3 | 22 (6.3%) | 0.645 (0.397, 1.050) | ||
| 4 | 109 (10.0%) | 1.000 (0.732, 1.366) | ||
| 5 | 129 (9.9%) | 0.996 (0.736, 1.350) | ||
| Constellation of CAD death, non-fatal MI or ischemic stroke | ≤2 | 55 (8.6%) | Referent, 0.4160 | |
| 3 | 21 (6.0%) | 0.697 (0.422, 1.153) | ||
| 4 | 101 (9.2%) | 1.040 (0.749, 1.445) | ||
| 5 | 111 (8.6%) | 0.960 (0.694, 1.327) | ||
| Cardiovascular Death | ≤2 | 12 (1.9%) | Referent, 0.2594 | |
| 3 | 5 (1.4%) | 0.756 (0.266, 2.147) | ||
| 4 | 28 (2.6%) | 1.301 (0.661, 2.561) | ||
| 5 | 42 (3.2%) | 1.602 (0.843, 3.044) | ||
| Components of the Primary Endpoint | CAD Death | ≤2 | 6 (0.9%) | Referent, 0.3998 |
| 3 | 2 (0.6%) | 0.618 (0.125, 3.062) | ||
| 4 | 18 (1.6%) | 1.752 (0.695, 4.417) | ||
| 5 | 19 (1.5%) | 1.503 (0.599, 3.768) | ||
| Nonfatal MI | ≤2 | 36 (5.7%) | Referent, 0.4349 | |
| 3 | 12 (3.4%) | 0.618 (0.322, 1.188) | ||
| 4 | 61 (5.6%) | 0.976 (0.646, 1.474) | ||
| 5 | 62 (4.8%) | 0.845 (0.560, 1.276) | ||
| Ischemic Stroke | ≤2 | 10 (1.6%) | Referent, 0.5215 | |
| 3 | 5 (1.4%) | 0.910 (0.311, 2.664) | ||
| 4 | 14 (1.3%) | 0.767 (0.340, 1.728) | ||
| 5 | 12 (0.9%) | 0.544 (0.235, 1.260) | ||
| Coronary Events3 | ≤2 | 83 (13.1%) | Referent, 0.3196 | |
| 3 | 46 (13.2%) | 1.027 (0.716, 1.472) | ||
| 4 | 167 (15.3%) | 1.166 (0.896, 1.517) | ||
| 5 | 207 (15.9%) | 1.245 (0.964, 1.607) | ||
| b: Relationship between the number of Metabolic Syndrome Criteria Met at Baseline and Primary/Secondary Endpoints 3 Criteria Referent | ||||
|---|---|---|---|---|
| Number of Metabolic syndrome criteria met at baseline |
Event Number (%) |
HR1 (95%CI), p- value2 |
||
| Primary Endpoint | 3 | 48 (13.8%) | Referent, 0.4467 | |
| 4 | 185 (16.9%) | 1.210 (0.881, 1.663) | ||
| 5 | 218 (16.8%) | 1.217 (0.890, 1.665) | ||
| Secondary Endpoints | Constellation of CAD death, non-fatal MI, ischemic stroke or hospitalization for ACS | 3 | 22 (6.3%) | Referent, 0.1433 |
| 4 | 109 (10.0%) | 1.552 (0.981, 2.454) | ||
| 5 | 129 (9.9%) | 1.553 (0.987, 2.442) | ||
| Constellation of CAD death, non-fatal MI or ischemic stroke | 3 | 21 (6.0%) | Referent, 0.2435 | |
| 4 | 101 (9.2%) | 1.496 (0.935, 2.395) | ||
| 5 | 111 (8.6%) | 1.384 (0.867, 2.208) | ||
| Cardiovascular death | 3 | 5 (1.4%) | Referent, 0.2319 | |
| 4 | 28 (2.6%) | 1.712 (0.661, 4.436) | ||
| 5 | 42 (3.2%) | 2.138 (0.845, 5.407) | ||
| Components of the Primary Endpoint | CAD Death | 3 | 2 (0.6%) | Referent, 0.3687 |
| 4 | 18 (1.6%) | 2.861 (0.664, 12.330) | ||
| 5 | 19 (1.5%) | 2.505 (0.583, 10.767) | ||
| Nonfatal MI | 3 | 12 (3.4%) | Referent, 0.3184 | |
| 4 | 61 (5.6%) | 1.589 (0.855, 2.951) | ||
| 5 | 62 (4.8%) | 1.379 (0.742, 2.562) | ||
| Ischemic Stroke | 3 | 5 (1.4%) | Referent, 0.5469 | |
| 4 | 14 (1.3%) | 0.847 (0.305, 2.352) | ||
| 5 | 12 (0.9%) | 0.600 (0.211, 1.704) | ||
| Coronary Events3 | 3 | 46 (13.2%) | Referent, 0.4417 | |
| 4 | 167 (15.3%) | 1.140 (0.822, 1.580) | ||
| 5 | 207 (15.9%) | 1.223 (0.888, 1.686) | ||
1
Cox regression models adjusted for treatment arm, sex and age. The number of criteria met as categorical term (HR comparing 3 vs 2, 4 vs. 2, 5 vs. 2).
2
p-values were calculated based on the Wald test.
3
Coronary events consist of death from coronary heart disease, non-fatal myocardial infarction, and hospitalization for acute coronary syndrome and coronary revascularization.
1
Cox regression models adjusted from treatment arm, sex, age. The number of criteria met as categorical term (HR comparing 4 vs. 3, 5 vs. 3).
2
p-values were calculated based on the Wald test.
3
Coronary events consist of death from coronary heart disease, non-fatal myocardial disease, hospitalization for acute coronary syndrome or coronary revascularization.