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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Trends Cell Biol. 2017 Jul 18;27(10):753–764. doi: 10.1016/j.tcb.2017.06.006

Figure 1.

Figure 1

Intestinal stem cell fate determination under basal conditions. In the resting state, reserve ISCs (blue) periodically divide to give rise to the active crypt base columnar stem cells (CBCs, green). These active CBCs then either produce transit-amplify progeny (T/A cells, dark grey), which go on to divide very rapidly in order to produce large quantities of enterocytes (light grey), or can generate secretory progenitor cells (maroon). These secretory progenitor cells then commit to Paneth, goblet, or enteroendocrine cell lineages (yellow, navy blue, or purple, respectively).