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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Exp Neurol. 2017 Aug 7;297:101–109. doi: 10.1016/j.expneurol.2017.08.002

Figure 5. Phosphomimetic HSPB1 expression in SOD1(G93A) astrocytes protects MNs from astrocyte-mediated toxicity.

Figure 5

A. MN survival at day 6 of MN co-culture assay with wild type, SOD1(G93A), SOD1(G93A) + HSPB1(TriA) or SOD1(G93A) + HSPB1(TriD) astrocytes. MN survival was normalized to counts from MNs cultured with wild type astrocytes. (n = 3 for all groups, each n was run in triplicate.) Error bars denote s.e.m. **P<0.001, ****P<0.0001, n.s., non-significant. B. Representative immunoblot confirming the expression of HSPB1(TriA) and HSPB1(TriD) in SOD1(G93A) astrocytes using an antibody specific to human HSPB1.