DNA vaccines PV-1947D (3hα-Syn85–99-MultiTEP;
A), PV-1948D
(3hα-Syn109–126-MultiTEP; B), PV-1949D
(3hα-Syn126–140-MultiTEP; C), and
PV-1950D
(3hα-Syn126–140-3hα-Syn109–126-3hα-Syn85–99-MultiTEP;
D) induced high titers of antibodies specific to appropriate
peptide/s. Endpoint titers of antibodies specific to
hα-Syn85–99,
hα-Syn109–126,
hα-Syn126–140 peptides were detected in sera
collected after the third immunization with indicated vaccines by ELISA. Lines
indicate the mean values of antibody titers
(**P<0.01,
****P<0.0001).