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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Neurobiol Aging. 2017 Jul 29;59:41–54. doi: 10.1016/j.neurobiolaging.2017.07.008

Figure 7. KL regulates postnatal neurogenesis.

Figure 7

A. Postnatal neurogenesis occurs as stem cells progress through a series of protein expression and morphological changes to mature into neurons. B. In brains without KL, with time, there is a loss of the stem/proliferative pool of cells but increased cell cycle re-entry consistent with a prematurely aging neurogenic niche. Decreased proliferation, decreased number of stem cells and immature neurons were measured, as was delayed maturation of immature neurons. C Overexpression of KL increases the number of stem cells/proliferative cells still present at 6 months. Increased proliferation and enhanced maturation allow a greater number of highly arborized immature neurons to persist in the dentate long after normal age-related downregulation of postnatal neurogenesis.