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. 2017 Sep 25;7:12259. doi: 10.1038/s41598-017-12539-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Results of GPA + PT + PCA for epicardium and endocardium in SS. For visualization purposes, only one per-group mean trajectory (300 Controls vs 300 MI) is shown. The colormap ranges from white ( = no deformation) to red (max) and refers to || xM-x || with xM the position at the Grand Mean and x its position at the PC axis extreme. As in SS the shapes are scaled to unit size and the deformations of epicardium and endocardium have different magnitudes, different color scales are used. The black line indicate the position of inter-ventricular septum. The PC scores of first three PCs are used as “landmarks” in the trajectory analysis taking in to account all 600 trajectories present in the dataset. See Supplementary Files 5 and 6 for dynamic visualization of trajectories and associated shape changes. Shapes are predicted at actual positive and negative axes extremes.