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. 2017 Sep 25;7:12230. doi: 10.1038/s41598-017-12061-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Annual number of FDA-approved NMEs between 2000 and 2015 and the average target number of yearly approved NMEs (the folding curve in red). Different types of drugs are colored according to the anatomical therapeutic chemical (ATC) classification system. The average target number of yearly approved NMEs fluctuates around the region of 2 to 5. (b) Average target numbers of approved NMEs by ATC since the year 2000. Values above the colored bars indicate the mean ± standard deviation of target numbers.