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. 2017 Sep 25;7:12292. doi: 10.1038/s41598-017-12548-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DDOST+/− mice have increased central adiposity despite greater physical activity. (A) Fat percentage measured by EchoMRI (left) and weight of omental fat deposits (right). (B,C) CLAMS apparatus measured 24 hour physical activity and caloric intake at 24 weeks post-dietary intervention in WT () and DDOST+/− () mice fed on either a high AGE diet (closed circles) or a low AGE diet (open circles). (B) Total locomotor activity in the horizontal plane measured by infrared beam breaks. (C) The line graphs show average hourly heat generation over the 24-hour period. The bar graphs on the right show the average physical activity over the entire 12-hour light/sleep (left) and dark/active (right) period. Data represented as means ± SD (n = 4–9/group). *P < 0.05, student’s t-test, α (genotype effect) P < 0.05, β (diet effect) P < 0.05, as per figure above. 2-way ANOVA and multiple comparison of genotype, diet and interaction by Bonferroni’s post hoc test.

Inline graphic — DDOST+/− mice have increased central adiposity despite greater physical activity. (A) Fat percentage measured by EchoMRI (left) and weight of omental fat deposits (right). (B,C) CLAMS apparatus measured 24 hour physical activity and caloric intake at 24 weeks post-dietary intervention in WT () and DDOST+/− () mice fed on either a high AGE diet (closed circles) or a low AGE diet (open circles). (B) Total locomotor activity in the horizontal plane measured by infrared beam breaks. (C) The line graphs show average hourly heat generation over the 24-hour period. The bar graphs on the right show the average physical activity over the entire 12-hour light/sleep (left) and dark/active (right) period. Data represented as means ± SD (n = 4–9/group). *P < 0.05, student’s t-test, α (genotype effect) P < 0.05, β (diet effect) P < 0.05, as per figure above. 2-way ANOVA and multiple comparison of genotype, diet and interaction by Bonferroni’s post hoc test.