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. 2017 Sep 25;7:12292. doi: 10.1038/s41598-017-12548-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A high AGE diet promotes liver fibrosis and correlates with increased ER stress markers following increases in DDOST+/− mice. (A) Immunofluorescence for OST48 (red), the ER stress marker GRP-78 (green) on paraffin liver sections (hepatocytes). (B) SWATH-MS protein intensities of ER stress pathway related proteins. GRP78 (top) and EIF3A (bottom). (C) SWATH-MS protein intensities of oxidative stress pathway related proteins. SODC (top) and SODM (bottom). (D) ELISA identifying content of urinary 8-isoprostane. Data represented as means ± SD (n = 4–9/group). *P < 0.05, MSstatsV3.5.1 determined significant log fold changes in the protein intensities between the selected experimental group and the WT low AGE diet group. Representative images scale bar = 20 µm.