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. 2017 Sep 25;7:12292. doi: 10.1038/s41598-017-12548-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DDOST+/− mice exhibit increased ketogenesis. (A) Concentrations of serum amino acids. (B) Heat map representation of SWATH-MS proteomics data for enzymatic pathways involved in ketogenesis. Significant proteins are represented as the Log₂ fold change where red indicates a decreased and blue indicates an increase in protein concentrations. Data represented as means ± SD (n = 4–9/group). For proteomics, MSstatsV3.5.1 determined significant (P < 0.05) log fold changes in the protein intensities between the selected experimental group the WT low AGE diet group.