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. 2017 Sep 25;8:692. doi: 10.1038/s41467-017-00741-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Contrast enhanced MRI with ZD2-Gd₃N@C80 of MDA-MB-231 and MCF-7 tumours in mice. a Representative axial T ₁-weighted 2D spin-echo MRI images of MDA-MB-231 and MCF-7 tumours in mice. Images were acquired before and at 10, 20 and 30 min after injection of ZD2-Gd₃N@C80 and hydroxylated Gd₃N@C80 at a dose of 1.67 µmol, or a mixture of 25 µmol kg⁻¹ free ZD2 and 1.67 µmol ZD2-Gd₃N@C80 (competitive group). Tumour locations are indicated by white arrow heads. b Analysis of percentage increase of tumour contrast-to-noise ratio (CNR) from images acquired in groups indicated in (a) (data are presented as mean ± s.e.m. n = 4 for MDA-MB-231 tumours and n = 3 for MCF-7 tumours. *P < 0.05 for comparison of the increased CNR ratio of ZD2-Gd₃N@C80 in MDA-MB-231 group with that in all the other groups). c Gd biodistribution at 1 week after injection of ZD2-Gd₃N@C80 or hydroxylated Gd₃N@C80 in MDA-MB-231 tumour models. There was no statistical difference between retention of the contrast agents in all the tested tissues (data are presented as mean ± s.e.m. n = 3)