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. 2017 Sep 25;7:12261. doi: 10.1038/s41598-017-12434-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pla2g3 ^−/− mice are protected against DSS-induced colitis. (a) Schematic representation of the procedure for DSS-induced colitis. (b,c) Daily monitoring of body weight loss (b) and clinical score (c) in Pla2g3 ^−/− and littermate Pla2g3 ^+/+ mice (8-week-old males) with or without DSS treatment (n = 16). (d,e) Gross appearance (d) and histology (e) of the colon in Pla2g3 ^+/+ and Pla2g3 ^−/− mice after treatment with DSS. Bar, 100 μm. (f) Scoring of proliferating CEC cells per section as determined by Ki67 staining of Pla2g3 ^+/+ and Pla2g3 ^−/− colons on day 4 (n = 3–5). (g) Quantitative RT-PCR of Pla2g3 and several inflammatory or epithelial barrier genes in the colon of Pla2g3 ^+/+ and Pla2g3 ^−/− mice after DSS treatment (n = 3–5). Mean ± SEM, *P < 0.05 and **P < 0.01. Data are from one experiment (f,g) or compiled from four experiments (b,c).