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. 2017 Sep 25;7:12261. doi: 10.1038/s41598-017-12434-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pla2g3 ^−/− mice are protected against colitis-induced colorectal cancer. (a) Schematic representation of the procedure for the AOM + DSS-induced colon cancer model. (b) Monitoring of survival rates of Pla2g3 ^−/− and littermate Pla2g3 ^+/+ mice following repeated DSS challenges. A representative result of three experiments, starting from 12 and 14 Pla2g3 ^+/+ and Pla2g3 ^−/− mice, respectively, is shown. (c) Quantitative RT-PCR of inflammation-associated genes in the colons of DSS-treated Pla2g3 ^+/+ and Pla2g3 ^−/− mice on day 56 (n = 3 and 9 for Pla2g3 ^+/+ and Pla2g3 ^−/− mice, respectively, in one experiment). (d) Gross appearance of the colons in Pla2g3 ^+/+ and Pla2g3 ^−/− mice after treatment with AOM + DSS on day 56. (e) Number of large (>2 mm) polyps per mouse in the colons of AOM + DSS-treated Pla2g3 ^+/+ and Pla2g3 ^−/− mice on day 56 (n = 23–29; compiled from two experiments). Mean ± SEM, *P < 0.05 and **P < 0.01.