Table 2.

Immunohistochemical analysis of ERα, ERβ, PR, ERα36, EGFR and HER2 expression in 218 PTCs, 156 nodular hyperplasias and 175 normal thyroid tissues according to the scoring system.

Score	ERα			ERβ			PR			ERα36			EGFR			HER2
	Normal	Nodular	PTCs	Normal	Nodular	PTCs	Normal	Nodular	PTCs	Normal	Nodular	PTCs	Normal	Nodular	PTCs	Normal	Nodular	PTCs
	thyroid tissues	hyper-plasias		thyroid tissues	hyper-plasias		thyroid tissues	hyper-plasias		thyroid tissues	hyper-plasias		thyroid tissues	hyper-plasias		thyroid tissues	hyper-plasia
	(n)	(n)	(n)	(n)	(n)	(n)	(n)	(n)	(n)	(n)	(n)	(n)	(n)	(n)	(n)	(n)	(n)	(n)
0
Negative	99	15	6	3	4	16	95	12	4	143	103	9	146	102	5	147	105	5
+
1	21	11	14	7	12	33	25	14	16	28	51	14	24	50	12	26	48	10
2	16	22	16	11	19	61	14	20	21	4	2	20	5	4	15	2	3	14
3	17	27	32	27	23	47	14	22	25	0	0	31	0	0	26	0	0	25
4	11	23	41	29	32	28	12	26	36	0	0	32	0	0	28	0	0	29
++
6	7	19	46	35	39	17	10	33	32	0	0	32	0	0	36	0	0	39
8	3	15	32	43	20	15	5	27	43	0	0	34	0	0	38	0	0	36
+++
9	1	15	18	11	4	1	0	2	26	0	0	30	0	0	37	0	0	37
12	0	9	13	9	3	0	0	0	15	0	0	16	0	0	21	0	0	23

The immunohistochemical scores in PTCs, nodular hyperplasias and normal thyroid tissues were determined as the multiplication of proportion score and intensity score.