Table 5.
Correlation of concomitant expression of ERα36, EGFR and HER2 with ETE, LNM and TNM stage.
| ETE | LNM | TNM stage | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Absent n (%) | Present n (%) | P value | Absent n (%) | Present n (%) | P value | I–II n (%) | III–IV n (%) | P value | |
| Expression information | |||||||||
| (1) All of ERα36/EGFR/HER2 low expression | 21 (100.0) | 0 (0) | <0.001a | 21 (100.0) | 0 (0) | <0.001a | 21 (100.0) | 0 (0) | <0.001a |
| (2) ERα36 high expression; EGFR/HER2 low expression | 20 (100.0) | 0 (0) | <0.001b | 19 (95.0) | 1 (5.0) | <0.001b | 19 (95.0) | 1 (5.0) | <0.001b |
| (3) EGFR high expression; ERα36/ HER2 low expression | 38 (100.0) | 0 (0) | <0.001c | 31 (81.6) | 7 (18.4) | <0.001c | 31 (81.6) | 7 (18.4) | <0.001c |
| (4) HER2 high expression; ERα36/EGFR low expression | 36 (100.0) | 0 (0) | <0.001d | 29 (80.6) | 7 (19.4) | <0.001d | 30 (83.3) | 6 (16.7) | <0.001d |
| (5) ERα36/EGFR high expression; HER2 low expression | 4 (100.0) | 0 (0) | 0.016e | 2 (50.0) | 2 (50.0) | 0.001e | 2 (50.0) | 2 (50.0) | <0.001e |
| (6) ERα36/HER2 high expression; EGFR low expression | 9 (100.0) | 0 (0) | 0.001f | 4 (44.4) | 5 (55.6) | <0.001f | 4 (44.4) | 5 (55.6) | <0.001f |
| (7) EGFR/HER2 high expression; ERα36 low expression | 11 (100.0) | 0 (0) | <0.001g | 5 (45.5) | 6 (54.5) | <0.001g | 3 (27.3) | 8 (72.7) | <0.001g |
| (8) All of ERα36/EGFR/HER2 high expression | 31 (36.8) | 48 (63.2) | <0.001h | 2 (2.5) | 77 (97.5) | <0.001h | 1 (1.3) | 78 (98.7) | <0.001h |
| Evaluation index (Concomitant high expression of ERα36/EGFR/HER2) | Rate (%) | Rate (%) | Rate (%) | ||||||
| Sensitivity | 100.0 | 73.3 | 72.9 | ||||||
| Specificity | 81.8 | 98.2 | 99.1 | ||||||
| Positive predictive value(PPV) | 63.2 | 97.5 | 98.7 | ||||||
| Negative predictive value(NPV) | 100.0 | 79.9 | 79.1 | ||||||
| Diagnostic accuracy | 85.8 | 86.2 | 86.2 | ||||||
Correlation of concomitant expression of ERα36, EGFR and HER2 with ETE, LNM and TNM stage was measured by Chi-square test. a–gStand for significant differences between group (1)‒(7) and group (8), respectively; hstands for significant difference between groups with and without concomitant high expression of all the three molecules. P < 0.05 was considered to be statistically significant.