Fig. 4. Synergistic role of runt-related transcription factor 2 (Runx2) and Indian hedgehog (Ihh)/Gli2 signaling in regulation of chondrocyte maturation. Runx2 and Ihh/Gli2 signaling synergistically regulate chondrocyte maturation by interacting with activating transcription factor 4 (ATF4) and CCAAT/enhancer-binding protein beta (C/EBPβ). Cbfβ, core binding factor β.
