Table 6.
Drug | Sedationa | Hypotension/dizzinessb | Extrapyramidal side effectsc | Anticholinergic effectsd |
---|---|---|---|---|
Haloperidol | + | + | +++ | + |
Levomepromazine (methotrimeprazine) | +++ | +++ | ++ | +++ |
Chlorpromazine | +++ | +++ | ++ | +++ |
Olanzapine | +++ | + | + | ++ |
Quetiapine | +++ | ++ | + | +++ |
Risperidone | ++ | ++ | ++ | + |
Aripiprazole | ++ | + | + | + |
+ indicates frequency >2%, ++ indicates frequency >10%, +++ indicates frequency >30%, ↓ indicates decreased, ↑ indicates increased
aDue to antihistaminic effect of certain antipsychotics
bHypotension/dizziness: due to adrenergic side effects
cSee text for details
dPeripheral: blurred vision, dry mouth, constipation, ↓ bronchial secretion, ↓ sweating, difficulty urination, urinary retention, tachycardia; central: impairment of concentration and memory, ↑ confusion (delirium)