Table 2.
Summary of netosis induction by virulence factors at the cell surface of C. albicans.
| Component of C. albicans | Induction of netosis | Pathway | Involved receptors |
|---|---|---|---|
| β-Glucan | Yes | ROS-dependent | Dectin-1, Mac-1 |
| Mannan | Yes | Mixed* | Dectin-1(?), CD14, Mac-1, TLR2, TLR4 |
| Moonlight proteins (enolase) | Yes (poorly) | – | – |
| Adhesin (Als3) | No | – | – |
| Sap1 | Yes | ROS-dependent | ~ |
| Sap2 | Yes | ROS-dependent | ~ |
| Sap3 | No | – | ~ |
| Sap4 | Yes | Mixed* | CD11a, CD11b |
| Sap5 | No (poorly) | – | ~ |
| Sap6 | Yes | Mixed* | CD11b, CD11a, CD14, TLR2 |
| Sap7 | No (poorly) | ~ | |
| Sap8 | Yes | ROS-dependent | ~ |
| Sap9 | Yes | ROS-dependent | CD16, CD18, CD11a, CD11b |
| Sap10 | Yes | ROS-dependent | CD16, CD18, CD14 |
*
ROS-dependent and ROS-independent; ~, not analyzed.