Table 1.

Sphingolipid metabolic enzymes.

Gene product	Worm ortholog	Alleles used	Known expression patterns	Human homolog	Protein similarity (%)
Sphingosine kinase	sphk-1	ok1097	Neuronal	Sphk1	72.5
			Hypodermis
			Intestine
			BW Muscle
Ceramide synthase	hyl-1	gk203	Ph Muscle	Ceramide synthase 6	71.9
			Intestine
			Neuronal
Ceramide synthase	hyl-2	ok1766	Ph Muscle	Ceramide sythase 4	67.7
			Intestine
			Neuronal
			Hypodermis
Ceramide kinase	cerk-1	ok1252		Cerk	70.9

BW, Body Wall; Ph, Pharynx.