Figure 2.

(A-I) TAK242 treatment ameliorated pathological airway structural changes in chronic asthmatic mice. (A, D and G) H&E staining was performed to evaluate the general structural changes of the airways, and (B, E and H) Masson's thichrome and (C, F and I) PAS staining was conducted on the lung sections to visualize collagen deposition and goblet cells, respectively. Magnification, ×20. The white arrows indicate the inflammatory cell infiltration, red frames indicate thickened airway walls, peribronchial collagen deposition and subepithelial fibrosis, and the black arrowheads indicate goblet cell hyperplasia. H&E, hematoxylin and eosin; HDM, house dust mites; PAS, periodic acid-schiff.