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. 2017 Jul 13;6(9):604–613. doi: 10.1002/psp4.12210

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© 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Model structure. AC_U, unbound active concentration (sunitinib + SU12662); β, regression coefficient; CL_m, clearance of the metabolite SU12262; f_m, fraction metabolized to SU12662; k_a, absorption rate constant; k_in, zero‐order release rate constant; k_out, first‐order elimination rate constant; λ₀, baseline hazard; Q, inter‐compartmental clearance of sunitinib; Q_H, liver blood flow; Q_m, intercompartmental clearance of the metabolite SU12662; V₁, volume of the central compartment of sunitinib; V_1,m, volume of the central compartment of the metabolite SU12662; V₂, volume of the peripheral compartment of sunitinib; V_2,m volume of the peripheral compartment of the metabolite SU12662.