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. 2017 Jul 13;6(9):604–613. doi: 10.1002/psp4.12210

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© 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Prediction‐corrected visual predictive checks of (a) the final pharmacokinetic (PK) model of sunitinib, (b) the final PK model of SU12662, (c) the soluble vascular endothelial growth factor receptor (sVEGFR)‐2 model, and (d) the sVEGFR‐3 model for one treatment cycle. Solid lines indicate the estimated mean as well as the 90% prediction interval. Dashed lines show the respective observed mean and interval. Shaded gray areas represent the 90% confidence band of the predictions. The dark gray rectangle indicates the time of treatment.