Figure 6.

Fluorescence values of HEK293T cells transfected with WT or mutant 3′-UTR DNA sequences of VEGF-C and agomiR-186. A dual luciferase reporter assay was used to evaluate the interaction between miR-186 and VEGF-C. Fluorescence values in the WT group were significantly lower than the control, while the values in the mutant group were not significantly different from the control values. **P<0.01 vs. NC. Data are presented as the mean ± standard deviation. VEGF-C, vascular endothelial growth factor C; WT, wild type; UTR, untranslated region; NC, negative control.