Table 3.

DSS treatment increased the transcripts associated with Th1 response.

Th1-associated transcription factor and cytokines
Tbet	Proximal colon		Distal colon
	Control mice	DSS-treated mice	Control mice	DSS-treated mice
Cycle 1	0.63 ± 0.22	0.51 ± 0.12	0.38 ± 0.08	1.52 ± 0.24**
Cycle 2	1.45 ± 0.31	1.76 ± 0.29	0.48 ± 0.09	1.65 ± 0.39**
Cycle 3	1.16 ± 0.22	1.20 ± 0.03	0.40 ± 0.11	1.27 ± 0.11**
Ifnγ	Proximal colon		Distal colon
	Control mice	DSS-treated mice	Control mice	DSS-treated mice
Cycle 1	0.01 ± 0	0.19 ± 0.11*	0.01 ± 0	0.82 ± 0.13*
Cycle 2	0.05 ± 0.01	0.31 ± 0.11*	0.03 ± 0.01	0.67 ± 0.18***
Cycle 3	0.04 ± 0.02	0.43 ± 0.16ρ = 0.058	0.05 ± 0.04	0.92 ± 0.12***
Il12	Proximal colon		Distal colon
	Control mice	DSS-treated mice	Control mice	DSS-treated mice
Cycle 1	0.20 ± 0.07	0.31 ± 0.09	0.30 ± 0.09	1.23 ± 0.18***
Cycle 2	0.52 ± 0.05	0.31 ± 0.05*	0.36 ± 0.03	0.89 ± 0.18*
Cycle 3	0.88 ± 0.18	0.64 ± 0.18	0.74 ± 0.13	1.03 ± 0.11

Colons were collected for examination of the mRNA expression level of Th1 transcription factors and associated cytokines. The mRNA expressions of Tbet, Ifnγ and Il12 in the proximal- and distal part of the colon are shown. All results are expressed as + SEM, n = 6. ^* indicates the significant different between control and DSS-treated mice.

^*P < 0.05.

^**P < 0.01.

^***P < 0.001.